Depo testosterone during pregnancy is possible only when the expected benefit to the mother outweighs the potential risk to the fetus. Data on the allocation of ursodeoxycholic acid in breast milk are not currently available. If necessary, the use lactation should decide the issue of termination of breastfeeding.
Dosing and Administration
Inside, squeezed a small amount of water.
To dissolve cholesterol gallstones average daily dose is 10-15 mg / kg. Treatments – 6-12 months or longer to complete dissolution of the stones. If cholelithiasis entire daily dose taken once at night.
It is recommended to use the drug for prevention of recurrent stone formation within a few months after the dissolution of stones.
After cholecystectomy for prevention of recurrence of cholelithiasis – 250 mg 2 times a day for several months.
In chronic hepatitis of various origin (toxic, drug, etc.), chronic viral hepatitis, non-alcoholic fatty liver disease, including nonalcoholic steatohepatitis, alcoholic liver disease, the average daily dose is 10-15 mg / kg 2-3 hours. The duration of therapy is 6-12 months or more.
When cholestatic liver disease of various origins, including primary biliary cirrhosis, primary sclerosing cholangitis, cystic fibrosis (cystic fibrosis), the average daily dose is 12-15 mg / kg; if necessary, the average daily dose may be increased to 20-30 mg / kg 2-3 hours. The duration of therapy is 6 months to a few years.
When biliary dyskinesia hypokinetic type on the average daily dose is 10 mg / kg in 2 divided doses for 2 weeks to 2 months. If necessary, treatment is recommended to repeat.
If biliary reflux gastritis and reflux depo testosterone esophagitis – 250 mg a day, at bedtime. The course of treatment – from 10-14 days to 6 months, if necessary – up to 2 years.
Diarrhea (may be dose-dependent).
Rare calcination gallstones, transient (transient) increase in the activity of “liver” enzymes, nausea, vomiting, abdominal pain, allergic reactions.
Cases of overdose are not known.
The interaction with other drugs
Antacids containing aluminum and ion exchange resins (colestyramine), reduce the absorption. Lipid-lowering agents (especially clofibrate), estrogens, progestins or neomycin increased saturation of bile with cholesterol and may reduce the ability to dissolve cholesterol gallstones.
Before the drug to dissolve gallstones need to meet the following conditions: stones should be cholesterol (roentgen), their size should not exceed 15-20 mm, the gallbladder must be functional and must be filled with stones not more than half, permeability cystic and common bile duct should be maintained.
with long-term (more than 1 month) taking the drug to depo testosterone dissolve gallstones, every 4 weeks during the first 3 months of treatment in the future – every 3 months to conduct a biochemical blood test to determine the activity of “liver” transaminases . Monitoring the effectiveness of the treatment should be carried out every 6 months by ultrasound biliary tract. After complete dissolution of the stones is encouraged to continue to use the drug for 3 months in order to facilitate the dissolution of rock residues that are too small for the detection and prevention of recurrence of stone formation.