During treatment with is testosterone a steroid should be monitored carefully for the sick. It is necessary to carry out blood tests to check liver function and. When the manifestation of hematological toxicity of the drug is recommended to decrease the daily dose of 1 capsule for the remainder of treatment.
Not less the manifestation of haematological toxicity of the drug treatment and calcium folinate interrupted until recovery of granulocytes to the level of not less than 1500 / l and platelet count to a level / l. To repeat courses should be reduced by 1 capsule.
If you change dose of calcium folinate is not changed.
With a deficit of risk of toxicity of the drug increases.
Because of the toxicity together with drugs that suppress the enzyme , need a break before taking to restore the activity of endogenous and fluorinated pyrimidines. Abdominal pain and / or diarrhea may be the first signs of severe enteritis. When they occur drug treatment should be discontinued. Symptoms of liver function abnormalities are loss of appetite, yellowing of the sclera (jaundice). If you have symptoms of liver dysfunction should stop taking and appropriate treatment.
If you have symptoms of central nervous system disturbances should discontinue treatment .
In patients older than 65 years, a few more common side effects such as anemia, diarrhea and inflammation of the gastrointestinal mucosa tract.
UFT is shown as a first-line drug for the treatment of metastatic cancer of the colon and rectum in combination with calcium folinate.
- Hypersensitivity to tegafur, uracil or any other ingredients in the preparation.
- Severe hepatic dysfunction
- Inhibition of bone marrow function due to their prior radiation or chemotherapy
- Confirmed deficit isoenzyme cytochrome is testosterone a steroid liver
- Confirmed dihydropyrimidine dehydrogenase deficiency
- The combination with an inhibitor of dihydropyrimidine dehydrogenase brivudine
- Gastric ulcer and duodenal ulcer
- Pregnancy and breast-feeding.
- Children up to 18 years.
Dosage and administration Standard treatment regimen: 300-600 mg of tegafur (3-6 capsules) divided into 2-3 doses. In combination with other anticancer dose adjustment is required. Is testosterone a steroid dose may be increased or decreased depending on patient tolerability. Tegafur daily dose should not exceed 600 mg. In combination with calcium folinate drug dose is calculated according to body surface area.